Published Work
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Parlakgül G, Arruda AP, Pang S, Cagampan E, Min N, Güney E, Lee GY, Inouye K, Hess HF, Xu CS, Hotamisligil G. Regulation of liver subcellular architecture controls metabolic homeostasis. Nature. Epub 2022 Mar 9. https://doi.org/10.1038/s41586-022-04488-5 Abstract
Güney E, Arruda AP, Parlakgul G, Cagampan E, Min N, Lee GY, Greene L, Tsaousidou E, Inouye K, Han MS, Davis RJ, Hotamisligil GS. Aberrant Ca2+ signaling by IP3Rs in adipocytes links inflammation to metabolic dysregulation in obesity. Sci Signal. 2021 Dec 14;14(713):eabf2059. doi: 10.1126/scisignal.abf2059. Epub 2021 Dec 14. PMID: 34905386. Abstract
Prentice KJ, Saksi J, Robertson LT, Lee GY, Inouye KE, Eguchi K, Lee A, Cakici O, Otterbeck E, Cedillo P, Achenbach P, Ziegler AG, Calay ES, Engin F, Hotamisligil GS. A hormone complex of FABP4 and nucleoside kinases regulates islet function. Nature. 2021 Dec;600(7890):720-726. doi: 10.1038/s41586-021-04137-3. Epub 2021 Dec 8. PMID: 34880500. Abstract
Tirosh A, Tuncman G, Calay ES, Rathaus M, Ron I, Tirosh A, Yalcin A, Lee YG, Livne R, Ron S, Minsky N, Arruda AP, Hotamisligil GS. Intercellular transmission of hepatic ER stress in obesity disrupts systemic metabolism. Cell Metab. 2020 Dec; DOI: 10.1016/j.cmet.2020.11.009 Abstract
Parlakgul G, Arruda AP, Cagampan E, Pang S, Guney E, Lee YG, Hess H, Xu CS, Hotamisligil GS. High resolution 3D imaging of liver reveals a central role for subcellular architectural organization in metabolism. bioRxiv. 2020 Nov; DOI: 10.1101/2020.11.18.387803
Guney E, Arruda AP, Parlakgul G, Cagampan E, Min N, Lee YG, Greene L, Tsaousidou E, Inouye KE, Han MS, Davis RJ, Hotamisligil GS. Aberrant Ca2+ homeostasis in adipocytes links inflammation to metabolic dysregulation in obesity. bioRxiv. 2020 Oct; DOI: 10.1101/2020.10.28.360008
Zhang Z, Qian Q, Li M, Shao F, Ding WX, Lira VA, Chen S, Sebag S, Hotamisligil GS, Cao H, Yang L. The unfolded protein response regulates hepatic autophagy by sXBP1-mediated activation of TFEB. Autophagy. 2020 Jul; DOI: 10.1080/15548627.2020.1788889 Abstract
Goncalves R, Schlame M, Bartelt, Brand MD, Hotamisligil G. An unexpected lack of difference in superoxide/H2O2 production rates in isolated heart and skeletal muscle mitochondria from a mouse model of Barth Syndrome. bioRxiv. 2020 May; DOI: 10.1101/2020.05.07.083105 Abstract
Goncalves R, Hotamisligil G. TMEM2 Modulates ER Stress in a Non-canonical Manner. Cell Metab. 2019 Dec; DOI: 10.1016/j.cmet.2019.11.008. Abstract
Liu C, Ren J, Wang Y, Zhang X, Sukhova GK, Liao M, Santos M, Luo S, Yang D, Xia M, Inouye K, Hotamisligil G, Lu G, Upchurch GR, Libby P, Guo J, Zhang J , Shi G. Adipocytes Promote interleukin-18 Binding to Its Receptors During Abdominal Aortic Aneurysm Formation in Mice. Eur Heart J. 2019 Dec; DOI: 10.1093/eurheartj/ehz856. Abstract
Tirosh A, Calay ES, Tuncman G, Claiborn KC, Inouye KE, Alcala M, Rathaus M, Hollander KS, Ron I, Livne R, Heianza Y, Qi L, Shai I, Garg R, Hotamışlıgil G. The short-chain fatty acid propionate increases glucagon and FABP4 production, impairing insulin action in mice and humans. Science Translational Medicine. 2019 April; DOI:10.1126/scitranslmed.aav0120. Abstract | Full Text
Prentice KJ, Saksi J, Hotamışlıgil G. Adipokine FABP4 integrates energy stores and counter regulatory metabolic responses. Journal of Lipid Research. 2019 Jan; DOI:10.1194/jlr.S09179. Full Text
Bartelt A, Widenmaier SB, Schlein C, Johann K, Goncalves RS, Eguchi K, Fischer AW, Parlakgul G, Snyder NA, Nguyen TB, Bruns OT, Franke D, Bawendi MG, Lynes MD, O Leiria L, Tseng Y, Inouye KE, Arruda AP, Hotamışlıgil G. Brown adipose tissue thermogenic adaptation requires Nrf1-mediated proteosomal activity. Nature Medicine. 2018 Feb; DOI:10.1038/nm.4481. Abstract
Arruda AP, Pers BM, Parlakgul G, Güney E, Goh T, Cagampan E, Lee GY, Goncalves RL, Hotamışlıgil GS. Defective STIM-mediated store operated calcium entry in hepatocytes leads to metabolic dysfunction in obesity. eLife. 2017 Dec; DOI:10.7554/eLife.29968. Full Text
Widenmaier SB, Snyder N, Nguyen T, Arduini A, Lee GY, Arruda AP, Saksi J, Bartelt A, Hotamışlıgil GS. NRF1 Is an ER Membrane Sensor that Is Central to Cholesterol Homeostasis. Cell. 2017 Nov; DOI:10.1016/j.cell.2017.10.003. Abstract
Charles KN, Li M, Engin F, Arruda AP, Inouye K, Hotamışlıgil GS. Uncoupling of Metabolic Health from Longevity through Genetic Alteration of Adipose Tissue Lipid-Binding Proteins. Cell Reports. 2017 Oct; DOI:10.1016/j.celrep.2017.09.051. Abstract
Hotamışlıgil GS. Foundations of Immunometabolism and Implications for Metabolic Health and Disease. Immunity. 2017 Sep; DOI:10.1016/j.celrep.2017.09.051. Abstract
Garfinkel BP, Hotamışlıgil GS. ER Stress Promotes Inflammation through Re-wIREd Macrophages in Obesity. Molecular Cell. 2017 Jun; DOI:10.1016/j.molcel.2017.05.037. Abstract
Parlakgul G, Hotamışlıgil GS. Type I Interferons Interfere with Liver Glucose Metabolism. Cell Metabolism. 2017 Jun; DOI:10.1016/j.cmet.2017.05.009. Abstract
Hotamışlıgil GS. Inflammation, metaflammation and immunometabolic disorders. Nature. 2017 Feb; DOI:10.1038/nature21363. Abstract
Widenmaier SB, Hotamışlıgil GS. Immune Cell Intolerance for Excess Cholesterol. Immunity. 2016 Dec; DOI:10.1016/j.immuni.2016.12.006. Full Text
Erikci Ertunc M, Hotamışlıgil GS. Lipid Signaling and Lipotoxicity in Metabolic Inflammation: Indications for Metabolic Disease Pathogenesis and Treatment. Journal of Lipid Research. 2016 Jun; DOI:10.1194/jlr.R066514. Abstract
Yilmaz M, Claiborn KC, Hotamışlıgil GS. De Novo Lipogenesis Products and Endogenous Lipokines. Diabetes. 2016 Jun; DOI: 10.2337/db160251. Abstract | Full Text
Burak MF, Inouye KE, White A, Lee A, Tuncman G, Calay ES, Sekiya M, Tirosh A, Eguchi K, Birrane G, Lightwood D, Howells L, Odede G, Hailu H, West S, Garlish R, Neale H, Doyle C, Moore A, Hotamışlıgil GS. Development of a therapeutic monoclonal antibody that targets secreted fatty acid–binding protein aP2 to treat type 2 diabetes. Science Translational Medicine 2015 December 23 doi:10.1126/scitranslmed.aac6336. Abstract | PDF
Hotamışlıgil GS, Bernlohr DA. Metabolic functions of FABPs—mechanisms and therapeutic implications. Nature Reviews Endocrinology 2015 August 11 doi:10.1038/nrendo.2015.122. Abstract | PDF
Yang L, Calay ES, Fan J, Arduini A, Kunz RC, Gygi SP, Yalcin A, Fu S, Hotamışlıgil GS. S-Nitrosylation links obesity-associated inflammation to endoplasmic reticulum dysfunction. Science 2015 July 31 doi: 10.1126/science.aaa0079. Abstract | PDF
Arruda AP, Hotamışlıgil GS. Calcium Homeostasis and Organelle Function in the Pathogenesis of Obesity and Diabetes. Cell Metabolism 2015 doi: 10.1016/j.cmet.2015.06.010. Abstract | PDF
Fu S, Yalcin A, Lee GY, Li P, Fan J, Arruda AP, Pers BM, Yilmaz M, Eguchi K, Hotamışlıgil GS. Phenotypic assays identify azoramide as a small-molecule modulator of the unfolded protein response with anti diabetic activity. Science Translational Medicine, 2015 June 17;7(292). Abstract | PDF
Nakamura T, Kunz RC, Zhang C, Kimura T, Yuan CL, Baccaro B, Namiki Y, Gygi SP, Hotamışlıgil GS. A critical role for PKR Complexes with TRBP in immunometabolic regulation and elF2α phosphorylation in obesity. Cell Reports 2015 doi:10.1016/j.celrep.2015.03.021. Abstract | PDF
Ertunc ME, Sikkeland J, Fenaroli F, Griffiths G, Daniels MP, Cao H, Saatcioglu F, Hotamışlıgil GS. Secretion of fatty acid binding protein aP2 from adipocytes through a non-classical pathway in response to adipocyte lipase activity. Journal of Lipid Research 2014 December 22 doi: 10.1194/jlr.M055798. Abstract | PDF
Arruda AP, Pers BM, Parlakgül G, Güney E, Inouye K, Hotamışlıgil GS. Chronic enrichment of hepatic endoplasmic reticulum–mitochondria contact leads to mitochondrial dysfunction in obesity. Nature Medicine 2014 December doi:10.1038/nm.3735. Abstract | Press Release | PDF
Engin F, Nguyen T, Yermalovich A, Hotamışlıgil GS. Aberrant islet unfolded protein response in type 2 diabetes. Sci Rep. 2014 Feb 11;4:4054. Abstract | PDF
Nakamura T, Furuhashi M, Baccaro B, Hotamışlıgil GS. Small molecule inhibitors of PKR improve glucose homeostasis in obese, diabetic mice. Diabetes, 2014. Feb;63(2):526-34. Abstract | PDF
Engin F, Yermalovich A, Nguyen T, Hummasti S, Fu W, Eizirik DL, Mathis D, Hotamışlıgil GS. Restoration of the unfolded protein response in pancreatic β cells protects mice againt type 1 diabetes. Science Transl Med., 2013 Nov 13;5(211). Abstract | PDF
Cao H, Sekiya M, Ertunc ME, Burak MF, Mayers JR, White A, Inouye K, Rickey LM, Ercal BC, Furuhashi M, Tuncman G, Hotamışlıgil GS. Adipocyte lipid chaperone AP2 is a secreted adipokine regulating hepatic glucose production. Cell Metab., 2013 May 7;17(5):768-78. Abstract | PDF
Gregor MF, Misch ES, Yang L, Hummasti S, Inouye KE, Lee AH, Bierie B, Hotamışlıgil GS. The Role of Adipocyte XBP1 in Metabolic Regulation during Lactation. Cell Reports, 2013 May 30;3(5):1430-9. Abstract | PDF
Fu S, Fan J, Blanco J, Gimenez-Cassina A, Danial NN, Watkins SM, Hotamışlıgil GS. Polysome profiling in liver identifies dynamic regulation of endoplasmic reticulum translatome by obesity and fasting. PLoS Genetics, 2012, 8(8):e1002902. Abstract | PDF
ten Freyhaus H, Calay ES, Yalcin A, Vallerie SN, Yang L, Calay ZZ, Saatcioglu F, Hotamışlıgil GS. Stamp2 controls macrophage inflammation through nicotinamide adenine dinucleotide phosphate homeostasis and protects against atherosclerosis. Cell Metab., 2012, 16:81-9. Abstract | PDF
Fu S, Watkins SM, Hotamışlıgil GS. The role of endoplasmic reticulum in hepatic lipid homeostasis and stress signaling. Cell Metab., 2012 May 2;15(5):623-34. Abstract | PDF
Gregor MF, Hotamışlıgil GS. Inflammatory mechanisms in obesity. Annual Reviews Immunology, 2011. Abstract | PDF
Fu S, Yang L, Li P, Hoffman O, Dicker L, Hide W, Lin X, Watkins, SM, Ivanov A, Hotamışlıgil GS. Aberrant lipid metabolism disrupts calcium homeostasis causing liver ER stress in obesity. Nature, 2011, 473; 528-531. Abstract | PDF
Mozaffarian D, Cao H, King IB, Lemaitre RN, Song X, Siscovick DS, Hotamışlıgil GS. Trans-Palmitoleic Acid, Metabolic Risk Factors, and New-Onset Diabetes in US Adults. Ann Intern Med 2010, 21;153:790-9. Abstract | PDF
Yang L, Li P, Fu S, Calay ES, Hotamışlıgil GS. Defective hepatic autophagy in obesity promotes ER stress and causes insulin resistance. Cell Metabolism, 2010, 11(6):467-478. Abstract | PDF
Hotamışlıgil GS. Endoplasmic Reticulum stress and the inflammatory basis of metabolic disease. Cell, 2010, 140(6):900-917. Abstract | PDF
Nakamura T, Furuhashi M, Li P, Cao H, Tuncman G, Sonenberg N, Gorgun CZ, Hotamışlıgil GS. Double-stranded RNA-dependent protein kinase links pathogen sensing with stress and metabolic homeostasis. Cell, 2010, 140(3):338-348. Abstract | PDF
Erbay E, Babaev VR, Mayers JR, Makowski L, Charles KN, Snitow M, Fazio S, Wiest MM, Watkins SM, Linton MF, Hotamışlıgil GS. Reducing endoplasmic reticulum stress through a macrophage lipid chaperone alleviates atherosclerosis. Nature Medicine, 2009, 12:1383-91. Abstract | PDF
Cao H, Gerhold K, Mayers JR, Wiest MM, Watkins SM, Hotamışlıgil GS. Identification of a lipokine, a lipid hormone linking adipose tissue to systemic metabolism. Cell, 2008, 134(6):933-44. Abstract | PDF
Furuhashi M, Fucho R, Gorgun CZ, Tuncman G, Cao H, Hotamışlıgil GS. Adipocyte/macrophage fatty acid–binding proteins contribute to metabolic deterioration through actions in both macrophages and adipocytes in mice. J Clin Invest, 2008, doi:10. 1172/JCI34750. Abstract | PDF
Furuhashi M, Tuncman G, Gorgun CZ, Makowski L, Atsumi G, Vaillancourt E, Kono K, Babaev VR, Fazio S, MacRae FL, Sulsky R, Robl JA, Parker RA, Hotamışlıgil GS. Treatment of diabetes and atherosclerosis by inhibiting fatty-acid-binding protein aP2. Nature, 2007, 447:959-965. Abstract | PDF
Wellen K, Fucho R, Gregor M, Furuhashi M, Morgan C, Lindstad T, Vaillancourt E, Gorgun C, Saatcioglu F, Hotamışlıgil GS. Coordinated regulation of nutrient and inflammatory responses by STAMP2 is essential for metabolic homeostasis. Cell, 2007, 129(3):537-48. Abstract | PDF
Hotamışlıgil GS. Inflammation and metabolic disorders. Nature, 2006, 444(7121):860-7. Abstract | PDF
Shum BOV, Mackay CR, Gorgun CZ, Frost MJ, Kumar RK, Hotamışlıgil GS, Rolph MJ. The adipocyte fatty acid–binding protein aP2 is required in allergic airway inflammation. JCI, 2006, 116(8):2183–2192. Abstract | PDF
Ozcan U, Yilmaz E, Ozcan L, Furuhashi M, Vaillancourt E, Smith RO, Gorgun CZ, Hotamışlıgil GS. Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes. Science, 2006, 313(5790):1137-40. Abstract | PDF
Cao H, Maeda K, Gorgun CZ, Kim HJ, Park SY, Shulman GI, Kim JK, Hotamışlıgil GS. Regulation of metabolic responses by adipocyte/ macrophage fatty acid–binding proteins in leptin-deficient mice. Diabetes, 2006, 55(7):1915-22. Abstract | PDF
Tuncman G, Hirosumi J, Solinas G, Chang L, Karin M, Hotamışlıgil GS. Functional in vivo interactions between JNK1 and JNK2 isoforms in obesity and insulin resistance. Proc Natl Acad Sci USA, 2006, 103(28):10741-46. Abstract | PDF
Tuncman G, Erbay E, Hom X, De Vivo I, Campos H, Rimm EB, Hotamışlıgil GS. A genetic variant at the fatty acid-binding protein aP2 locus reduces the risk for hypertriglyceridemia, type 2 diabetes, and cardiovascular disease. Proc Natl Acad Sci USA, 2006, 103(18):6970-5. Abstract| PDF
Wellen KE, Hotamışlıgil GS. Inflammation, stress, and diabetes. J Clin Invest, 2005, 115:1111-1119. Abstract | PDF
Tong Q, Tsai J, Tan G, Dalgin G, Hotamışlıgil GS. Interaction between GATA and the C/EBP family of transcription factors is critical in GATA-mediated suppression of adipocyte differentiation. Mol Cell Bio 2005, 25(2): 706-715. Abstract | PDF
Maeda K, Cao H, Kono K, Gorgun CZ, Furuhashi M, Uysal KT, Cao Q, Atsumi G, Malone H, Krishnan B, Minokoshi Y, Kahn BB, Parker RA, Hotamışlıgil GS. Adipocyte/macrophage fatty acid binding proteins control integrated metabolic responses in obesity and diabetes. Cell Metabolism, 2005, 1:107-119. Abstract | PDF
Makowski L, Brittingham KC, Reynolds JM, Suttles J, Hotamışlıgil GS. The fatty acid-binding protein, aP2, coordinates macrophage cholesterol trafficking and inflammatory activity. Macrophage expression of aP2 impacts peroxisome proliferator-activated receptor gamma and IkappaB kinase activities. J Biol Chem, 2005, epublication. Abstract | PDF
Ozcan U, Cao Q, Yilmaz E, Lee AH, Iwakoshi NN, Ozdelen E, Tuncman G, Gorgun C, Glimcher LH, Hotamışlıgil GS. Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes. Science, 2004, 306:457-61. Abstract | PDF
Boord JB, Maeda K, Makowski L, Babaev VR, Fazio S, Linton MF, Hotamışlıgil GS. Combined adipocyte-macrophage fatty acid-binding protein deficiency improves metabolism, atherosclerosis, and survival in apolipoprotein E-deficient mice. Circulation, 2004, 110(11):1492-1498. Abstract | PDF
Maeda K, Uysal KT, Makowski L, Gorgun CZ, Atsumi G, Parker RA, Bruning J, Hertzel AV, Bernlohr DA, Hotamışlıgil GS. Role of the Fatty Acid Binding Protein mal1 in obesity and insulin resistance. Diabetes, 2003, 52: 300-307. Abstract | PDF
Xu, H, Uysal, KT, Becherer, D, Arner, P, Hotamışlıgil GS. ALTERED TNF a Altered tumor necrosis factor-alpha (TNF-alpha) processing in adipocytes and increased expression of transmembrane TNF-alpha a in obesity. Diabetes, 2002, 51:1876-1883. Abstract | PDF
Boord, JB, Maeda, K, Makowski, L, Babaev, VR, Fazio, S, Linton, MF, Hotamışlıgil GS. Adipocyte fatty acid-binding protein, aP2, alters late atherosclerotic lesion formation in severe hypercholesterolemia. Art, Thro, Vasc Bio, 2002, 22:1686-1691. Abstract | PDF
Hirosumi, J, Tuncman, G, Chang, L, Gorgun, CZ, Uysal, KT, Maeda, K, Karin, M, Hotamışlıgil GS. A central role for JNK in obesity and insulin resistance. Nature, 2002,420:333-336. Abstract | PDF
Makowski L, Boord JB, Maeda K, Babaev VR, Uysal KT, Morgan MA, Parker RA, Suttles J, Fazio S, Hotamışlıgil GS, Linton MF. Lack of macrophage fatty-acid-binding protein aP2 protects mice deficient in apolipoprotein E against atherosclerosis. Nature Medicine. 7(6):699-705, 2001. Abstract | PDF
Tong Q, Dalgin G, Xu H, Ting CN, Leiden JM, Hotamışlıgil GS. Function of GATA transcription factors in preadipocyte-adipocyte transition. Science. 290(5489):134-138, 2000. Abstract | PDF
Scheja L, Makowski L, Uysal KT, Wiesbrock SM, Shimshek DR, Meyers DS, Morgan M, Parker RA and Hotamışlıgil GS. Altered insulin secretion associated with reduced lipolytic efficiency in aP2-/- mice. Diabetes, 1999 Oct; 48:1987-1994. Abstract | PDF
Xu H, Sethi JK, Uysal KT, Wiesbrock SM, Scheja L and Hotamışlıgil GS. Transmembrane Tumor Necrosis Factor (TNF)-a Inhibits adipocyte differentiation by selectively activating TNF Receptor 1. J. Biol. Chem. 1999. 274(37):26287-26295. Abstract | PDF
Kirchgessner T, Uysal KT, Wiesbrock SM, Marino MW and Hotamışlıgil GS. Tumor necrosis factor-alpha contributes to obesity-related hyperleptinemia by regulating leptin release from adipocytes. Journal of Clinical Investigation 1997 Dec 1; 100(11): 2777-2782. Abstract | PDF
Uysal KT, Wiesbrock SM, Marino MW and Hotamışlıgil GS. Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function. Nature. 1997 Oct 9; 389(6651): 610-614. Abstract | PDF