Research Assistant Position Open 

The Hotamışlıgil Lab at the Sabri Ülker Center studies innate adaptive pathways involved in metabolic health and diseases such as obesity, diabetes, cardiovascular disease and asthma. For the past 25 years, our lab has made important contributions to the burgeoning field of “immunometabolism", studying the interactions between metabolic and immune responses as critical drivers of numerous chronic diseases. In the last decade, we have approached immunometabolism in these two paths: organelle homeostasis and lipid metabolism. Using biochemical, genetic, and physiological studies, we aim to find novel pathways and preventive, therapeutic solutions to today’s greatest threats to global human health. The environment in our laboratory is collegial, supportive and diverse. One of the greatest powers of science is its ability to unite people, where representatives from every nation, culture, ethnicity, religion, and lifestyle  can work together for a common purpose. This is most evident in the Sabri Ülker Center, where we come together to tackle challenging questions and dream to make a positive impact on human life. 

 

We are looking for two (2) Research Assistants (RA) who are enthusiastic and excited about the work we do in our lab, and who want to make a strong scientific contribution to our research. These RA’s will work with genetically engineered mouse models and perform a wide variety of physiology experiments, including studies implementing advanced physiological instrumentation and surgeries. It is an opportunity to learn advanced techniques in molecular biology, protein and RNA purification and analysis, mammalian tissue culture, biochemical assays, immunostaining and microscopy. RA’s will follow up experiments by organizing, processing and reporting data. RA’s are expected to be fully engaged in the intellectual activities of the lab and actively participate in lab meetings and discussions.

 

One RA will work primarily with our Director of Animal Studies. Experience in performing animal studies preferred. Primary responsibilities include, but are not limited to:

  • Performing mouse metabolic physiology experiments.

  • Maintaining mouse colonies, including breeding and genotyping.

  • Processing mouse blood and tissue samples for protein and RNA analysis.

  • Maintaining cell cultures and performing cell culture experiments.

  • Assisting lab members with mouse physiology experiments.

 

One RA will work on a project studying the role of protein degradation in health and disease using multiple techniques both in-vivo and in primary cellular models. Primary responsibilities include, but are not limited to:

  • Generation and maintenance of several strains of mice and appropriately matched controls.

  • Analysis of these animal models including highly sophisticated experimentation, reconstitution, primary cell preparations, biochemical and molecular analysis and physiological phenotype analysis.

  • Maintaining cell cultures and performing cell culture experiments.

 

Requirements: BS/MS in biological sciences. One year of related work experience (relevant course work may count towards experience). Experience in basic molecular and cellular biology techniques. High level of initiative and motivation; ability to work independently and with a team. Excellent communication, organization, time management, and record-keeping skills. Strong organizational skills and experience in handling sensitive and confidential information.

 

Compensation: Competitive salary. Excellent benefits. Annual paid time off includes 15 days of vacation, 3 personal days, 12 sick days; 11.5 paid holidays plus a Winter Recess during the week between Christmas and New Year’s Day.

 

Application Instructions: Send resume and cover letter to sabriulkercenter@hsph.harvard.edu

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