Career Opportunities with the Hotamışlıgil Lab 

 

The Hotamışlıgil Lab at the Sabri Ülker Center studies innate adaptive pathways involved in metabolic health and diseases such as obesity, diabetes, cardiovascular disease and asthma. For the past 25 years, our lab has made important contributions to the burgeoning field of “immunometabolism", studying the interactions between metabolic and immune responses as critical drivers of numerous chronic diseases. In the last decade, we have approached immunometabolism in these two paths: organelle homeostasis and lipid metabolism. Using biochemical, genetic, and physiological studies, we aim to find novel pathways and preventive, therapeutic solutions to today’s greatest threats to global human health. The environment in our laboratory is collegial, supportive and diverse. One of the greatest powers of science is its ability to unite people, where representatives from every nation, culture, ethnicity, religion, and lifestyle  can work together for a common purpose. This is most evident in the Sabri Ülker Center, where we come together to tackle challenging questions and dream to make a positive impact on human life. 

The Sabri Ülker Center is located in the Department of Molecular Metabolism at the Harvard TH Chan School of Public Health.  The Department of Molecular Metabolism seeks to find, develop, promote, and retain the world’s best scholars. We are committed to upholding the values of diversity, equity, and inclusion in our hiring process. The Department is keenly interested in diversifying its trainees and encourages applications from diverse candidates, including women and minorities. 

IMMEDIATE OPENING - IN VIVO Animal Physiology Research Assistant III

We are seeking an Animal Physiology Research Assistant (RA) who is enthusiastic and excited about the in vivo physiology work we do in our lab, wants to make a strong scientific contribution to our research, and has the interest in growing within the role. Reporting to the Director of Animal Research, this Research Assistant will work with genetically engineered mouse models and perform a wide variety of physiology experiments, including studies implementing advanced physiological instrumentation and surgeries. It is an opportunity to learn and perform advanced techniques in molecular biology, protein and RNA purification and analysis, mammalian tissue culture, biochemical assays, immunostaining, and microscopy, while supporting various research projects across the lab. The RA will also follow up experiments by organizing, processing, and reporting data. As such, this RA is expected to be fully-engaged in the intellectual activities of the lab and to actively participate in lab meetings and discussions.

 

Additional duties and responsibilities include, but are not limited to, the following:

 

  • Performing mouse metabolic physiology experiments Maintaining mouse colonies, including breeding and genotyping

  • Processing mouse blood and tissue samples for protein and RNA analysis Maintaining cell cultures and performing cell culture experiments

  • Assisting various lab members (across various projects) with mouse physiology experiments

  • Performing and supporting the analysis, interpretation, and reporting of data utilizing multiple software programs and scientific instrumentation

  • Participation and intellectual contribution to lab meetings, journal clubs, and data discussions Serving as back-up to the Director as needed

  • Performing other duties as assigned

 

PLEASE NOTE: This position has a term end date of 12/31/2023, with possibility for extension based on funding. It is also full- time, benefits-eligible with a 40 hour work week.

 

Basic Qualifications

3+ years of related work experience required; a combination of education and experience may be considered Experience in basic and advanced molecular and cellular biology techniques required

Additional Qualifications and Skills

The following job-specific skills and competencies are preferred:

  • Bachelor's degree strongly preferred

  • Experience handling small animals in a research setting IOS operating system device familiarity

  • Microsoft Office Suite experience (including Word, Excel and PowerPoint

  • Interested in making a commitment to grow in the position and assume increasing levels of responsibility Proven high level of initiative and motivation, and experience working independently and with a team

  • Proven excellence in communication, organization, time management, and record-keeping skills; demonstrated strong organizational skills

  • Excitement and interest specifically for in vivo physiology work as a profession The following cultural competencies are also preferred:

  • Awareness of and aptitude to appropriately and effectively understand, respect, and adapt to cultural and identity-based difference within group environments

  • Knowledge of and commitment to concepts and issues tied to social justice, diversity, equity, and inclusion

  • Skills related to creating and supporting an environment that allows for inclusion, effective intercultural engagement, and personal humility and authenticity

 

Harvard University offers an outstanding benefits package including:

  • Time Off: 3-4 weeks paid vacation, paid holiday break, 12 paid sick days, 12+ paid holidays, and 3 paid personal days per year.

  • Medical/Dental/Vision: Excellent and affordable medical, dental & vision plans, with coverage beginning as of an employee's start date.

  • Retirement: University-funded retirement plan with full vesting after 3 years of service.

  • Tuition Assistance & Reimbursement Programs: $40 per class at the Harvard Extension School, discounted options through participating Harvard graduate schools, and reimbursement options for accredited schools outside of Harvard. Transportation: 50% discount on MBTA passes, as well as additional options (rideshare, biking, etc.) to assist employees in their daily commute.

  • Wellness & Professional Development: Programs and classes at little or no cost, including stress management, hard & soft skills development, career planning, massages, nutrition, meditation, and complimentary health services.

  • Additionally, access to Harvard athletic facilities, libraries, campus events -- and many discounts for various cultural and leisure activities throughout metro Boston.

  • Join the Harvard T.H. Chan School of Public Health to support our mission of health research and education, and to be a part of the oldest institution of higher learning in the country!

Research Associate - Immunometabolism and Antibody Therapeutics
 

This novel position will develop and manage a research program focusing on the area of immunometabolism, glucose and lipid metabolism, hormone action, and its interface with antibody therapeutics against metabolic disease. Key activities include, but are not limited to, working with other scientists in the group to identify, develop and implement sophisticated research methods to pursue the following questions:
 

  • Biochemical and biophysical studies for target protein characterization and physiological and pathophysiological roles in disease states

  • Supervise, coordinate and/or directly engage in mechanistic studies to characterize target action

  • Development of cellular assays and facilitate their HTP implementation in partner labs, coordinate CRO activities

  • Activities for functional validation of antibodies generated by partners, coordinate CRO activities, and efforts on identification of biomarkers, and patient stratification, Mendelian stratification, etc., for clinical transition.

  • Exploration of a large animal model in addition to mice to produce a scalable supply of endogenous protein and other studies.

Additionally, this position will advise the PI in the development of research goals in this research area that could result in additional 3rd party relationships and in the eventual development of commercialization strategies. Evaluate project progress and advise the PI on alternative research strategies and methods to stimulate positive outcomes. Project management responsibilities for Ülker Center Strategic Alliance Research Portfolio include working with the Office of Technology Development to ensure that project milestones are achieved; reporting is provided to appropriate governance groups; manage interactions with research partners.

Additional information and application: https://academicpositions.harvard.edu/postings/10152 

TWO POSITIONS OPENING FOR RESEARCH ASSISTANTS IN IMMUNOMETABOLISM

June/July 2022 Start; Two-year positions with possibility of renewal

 

We are looking for two Research Assistants (RAs) who are enthusiastic and excited about the work we do in our lab, and who want to make a strong scientific contribution to our research. These RA’s will work with genetically engineered mouse models and perform a wide variety of physiology experiments, including studies implementing advanced physiological instrumentation and surgeries. It is an opportunity to learn advanced techniques in molecular biology, protein and RNA purification and analysis, mammalian tissue culture, biochemical assays, immunostaining and microscopy. RAs will follow up experiments by organizing, processing and reporting data. RAs are expected to be fully engaged in the intellectual activities of the lab and actively participate in lab meetings and discussions. RAs will work on a project studying the role of protein degradation in health and disease using multiple techniques both in-vivo and in primary cellular models. Primary responsibilities include, but are not limited to:


•    Generation and maintenance of several strains of mice and appropriately matched controls.
•    Analysis of these animal models including highly sophisticated experimentation, reconstitution, primary cell preparations, biochemical and molecular analysis and physiological phenotype analysis.
•    Maintaining cell cultures and performing cell culture experiments.

Requirements: BS/MS in biological sciences. One year of related work experience (relevant course work may count towards experience). Experience in basic molecular and cellular biology techniques. High level of initiative and motivation; ability to work independently and with a team. Excellent communication, organization, time management, and record-keeping skills. Strong organizational skills and experience in handling sensitive and confidential information.

Compensation: Competitive salary. Excellent benefits. Annual paid time off includes 15 days of vacation, 3 personal days, 12 sick days; 11.5 paid holidays plus a Winter Recess during the week between Christmas and New Year’s Day.

Application Instructions: Send resume and cover letter to sabriulkercenter@hsph.harvard.edu
 

Postdoctoral Fellow Opportunities
 

We are always looking for fellows who wish to join our laboratory who possess a deep commitment and passion for science and enjoy working in a rich, diverse environment where all members are part of building scientific knowledge as a community that collaborates, combines, compounds, and participates actively in a collective experience.

In science, every contribution is valuable and paves the way for important breakthroughs. Milestone discoveries lift the entire field as researchers around the world start building on top of this new foundation of knowledge. From a metabolic perspective, this is the kind of work we have been aspiring to and focus on at the Sabri Ülker Center. Collectively, we can make real progress against the most dangerous diseases.

We invite you to send your CV and a description of your research project to sabriulkercenter@hsph.harvard.edu